Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation

Neuroinflammation is a highly reactive response that has not been addressed due to its complexity. Some of molecular pathways, such as glycosylation, have neglected in the past. Despite intricacy and diversity glycome, there an increased interest this field study, which resulted fostering advances glycobiology glycochemistry. These supported emergence new class glyco-engineered approaches, biomaterial-based strategies can address different disease glycophenotypes. Even though these are extensively used yet, review aims provide resourceful toolbox build wide variety novel materials be designed tackle glyco-dysregulations seen neuroinflammation. By assembling already-well-described knowledge from chemistry, best both worlds harnessed toward biomaterial science branch study: polymeric-based glyco-modulatory materials.